Plasma Thromboplastin

The reaction of haemophilic plasma to thromboplastin.

A possible fourth plasma thromboplastin component.

Plasma Thromboplastin Antecedent ( PTA , Factor XI ) : A Specific and Sensitive

A specific, sensitive, and reproducible radioimmunoassay for human plasma thromboplastin antecedent (PTA, factor Xl) has been developed with purified PTA and monospecific rabbit antiserum. Precise measurements of PTA antigen were possible for concentrations as low as 0.3% of that in normal pooled plasma. Normal plasma contained approximately 6 zg PTA/mI. A good correlation (correlation coeffici...

The Identification and Synthesis of Activated Plasma Thromboplastin Component (ptc').

S THE NUMBER of known intrinsic clotting factors has increased, it has become clear that the final reaction, the conversion of fibrinogen to fibrin by thrombin, must result from a series of preliminary reactions, each probably involving only two clotting factors. This means that each clotting factor must circulate either as a precursor or as a highly specific molecule which only reacts with ano...

The prevalence of plasma thromboplastin antecedent (PTA, factor XI) deficiency.

By W. Angus Muir and Oscar D. Ratnoff P LASMA TH ROM BOPLASTIN antecedent (PTA, Factor X I) deficiency is an inherited disorder of blood coagulation characterized by a defect of the intrinsic pathway of thrombin formation and a mild to moderate bleeding tendency. Since the original description by Rosenthal, Dreskin, and Rosenthal,’ it has been reported in this country and in Europe to occur wit...